HORDB

General Information

ID: hor005763
Uniprot ID: P01042
Protein name: Low molecular weight growth-promoting factor
Gene name: KNG1
Organism: Homo sapiens (Human)
Family: NA
Source: Human
Expression: Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.
Disease: Diseases associated with KNG1 include High Molecular Weight Kininogen Deficiency and Angioedema, Hereditary, 6.
Comments: NA
Taxonomy: Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0004869 cysteine-type endopeptidase inhibitor activity; GO:0005102 signaling receptor binding; GO:0005179 hormone activity; GO:0005515 protein binding; GO:0008201 heparin binding; GO:0008270 zinc ion binding; GO:0030414 peptidase inhibitor activity
GO BP: GO:0006954 inflammatory response; GO:0007162 negative regulation of cell adhesion; GO:0007165 signal transduction; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007596 blood coagulation; GO:0007599 hemostasis; GO:0030195 negative regulation of blood coagulation; GO:0042311 vasodilation
GO CC: NA

Sequence Information

Sequence: WGHE
Length: 4(431-434)
Propeptide: MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNCDIYPGKD
Signal peptide: MKLITILFLCSRLLLSLT
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation
Mechanism: NA
Cross BBB: NA
Target: BDKRB2
Target Unid: P30411
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: AF-P01042-F1(AlphaFold_DB_ID)

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005763_AF2.pdb

hor005763_ESM.pdb

Physical Information

Mass:	58123	Formula:	C24H29N7O7
Absent amino acids:	ACDFIKLMNPQRSTVY	Common amino acids:	EGHW
pI:	5.36	Basic residues:	1
Polar residues:	1	Hydrophobic residues:	1
Hydrophobicity:	-200	Boman Index:	-820
Half-Life:	2.8 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	0
Instability Index:	-1842.5	Extinction Coefficient cystines:	5500
Absorbance 280nm:	1833.33

Literature

PubMed ID: 6441591
Title: Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen.
PubMed ID: 2989293
Title: Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of tw
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